Fate of human IgG from lupus erythematosus antinuclear antibody positive sera passively transfered to mice.
Rev Rhum Engl Ed
; 63(2): 111-8, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-8689281
An animal model to study the fate of antinuclear antibodies (ANA) in vivo is reported. Newborn Balb/c mice were passively transferred by injection with sera from patients with autoimmune disease. The following antinuclear antibodies were found in the liver, spleen, kidneys and skin shortly after the injection: anti-dsDNA, nRNP, Ro/SSA and La/SSB. Clearance of all these antibodies occurred within 48 hours. The cytoskeleton, Fc immunoglobulin domain and Fc immunoglobulin-cell surface interaction may play a major role in the entry of antinuclear antibodies into cells, which may occur via endocytosis. Our animal model may be useful for studying the kinetics of binding of antinuclear antibodies to nuclear components and the effects of such binding in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Anticorpos Anti-Idiotípicos
/
Anticorpos Antinucleares
/
Imunização Passiva
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Rev Rhum Engl Ed
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
França