The inflammatory response promotes cutaneous metastasis in hamsters infected with Leishmania (Viannia) panamensis.
J Parasitol
; 82(3): 454-7, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8636852
The influence of nonspecific and immunologically elicited inflammatory responses on the development of metastatic lesions was examined in the hamster model of Leishmania (Viannia) panamensis infection. Delayed type hypersensitivity (DTH) responses were induced using the contact sensitizing agent DNFB (2, 4-dinitro-1-fluorobenzene) and infection with L. panamensis followed by intradermal application of leishmanin. Nonspecific inflammatory response was achieved by the surgical excision of toes. The inductive and eliciting procedures were performed on the ears and fore and hind paws of the right side of experimental groups of hamsters that were inoculated in the snout with a highly metastatic strain of L. panamensis (MHOM/COL/84/1099). Skin metastases were detected by physical evaluation at 15-day intervals over a period of 7-8 mo. Suspected metastases were parasitologically confirmed by culture of tissue fluid aspirated from the lesion. The frequency of metastatic lesions was greater in hamsters subjected to inflammatory stimuli (14/38) than control animals (6/33; P = 0.035). Likewise, the frequency of metastases at the site of induction and elicitation of inflammation (18/22 lesions) in the experimental groups was greater than that observed at the same site in control animals (5/11 lesions; P = 0.017). These findings support a causal relationship between inflammatory response and the development of lesions in this model of secondary disease caused by L. panamensis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Leishmaniose Mucocutânea
/
Leishmania guyanensis
Tipo de estudo:
Prognostic_studies
Limite:
Animals
País/Região como assunto:
America central
/
Panama
Idioma:
En
Revista:
J Parasitol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Estados Unidos