Your browser doesn't support javascript.
loading
Possible role of bovine immunodeficiency virus in bovine paraplegic syndrome: evidence from immunochemical, virological and seroprevalence studies.
Walder, R; Kalvatchev, Z; Tobin, G J; Barrios, M N; Garzaro, D J; Gonda, M A.
Afiliação
  • Walder R; Laboratorio Virus Animales, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas.
Res Virol ; 146(5): 313-23, 1995.
Article em En | MEDLINE | ID: mdl-8578005
Bovine paraplegic syndrome (BPS) is a debilitating cattle disease of unknown origin that is characterized by leukocytosis, lymphocytopenia and monocytopenia. The major clinical signs are difficulties in locomotion affecting hind limbs, hypoalgesia in the hind quarters, posterior paralysis and death within 72 to 96 hours after recumbency. To investigate the aetiological basis of BPS, we examined a possible association of the syndrome with infection by bovine immunodeficiency virus (BIV), a lentivirus implicated in immune system dysfunction and central nervous system lesions in cattle. Serum samples (n = 1,278) were collected from both healthy and BPS-prevalent cattle herds in Venezuela, and organ extracts were prepared from euthanized animals (n = 11) suspected of having BPS. Sera were analysed for reactivity to recombinant BIV and bovine leukaemia virus gag precursor proteins by immunoblot procedures. Serum reactivity to BIV ranged from 12 to 66% between groups of BPS prevalent herds. The percentage of samples reactive to BLV antigen was much lower (2 to 17%). Rabbits inoculated with extracts from BPS-afflicted animals exhibited an anamnestic immune response to BIV antigens as well as the presence of BIV gag antigens in their tissues. We present evidence for a possible association between BPS disease and a viral agent related to BIV. The role of BIV, in combination with malnutrition, in BPS is discussed.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paraplegia / Doenças dos Bovinos / Infecções por Lentivirus / Vírus da Imunodeficiência Bovina Limite: Animals País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Res Virol Assunto da revista: VIROLOGIA Ano de publicação: 1995 Tipo de documento: Article País de publicação: França
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paraplegia / Doenças dos Bovinos / Infecções por Lentivirus / Vírus da Imunodeficiência Bovina Limite: Animals País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Res Virol Assunto da revista: VIROLOGIA Ano de publicação: 1995 Tipo de documento: Article País de publicação: França