Effects of misoprostol on circulating HDL-cholesterol, total cholesterol, triglycerides and their relationship with hepatic microsomal function.
Pharmacol Toxicol
; 77(4): 255-8, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-8577636
The effects of misoprostol (cytotec, SC29333) on circulating lipoproteins and liver microsomal enzyme activity were studied. Misoprostol increased serum levels of high density lipoprotein-cholesterol and decreased total cholesterol and triglycerides. The high density lipoprotein-cholesterol/total cholesterol ratio increased by 54.8%. In parallel, misoprostol significantly altered enzyme hepatic activity. Liver microsomal cytochromes P450 and b5 were significantly increased in correlation with enhanced liver aminopyrine N-demethylase and antipyrine hydroxylase activities, suggesting a liver induction effect of misoprostol. Other observations such as increased liver weight and glycogen and increased plasma albumin and glucose in rats receiving misoprostol support this evidence.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triglicerídeos
/
Microssomos Hepáticos
/
Colesterol
/
Misoprostol
/
HDL-Colesterol
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Toxicol
Assunto da revista:
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Dinamarca