Genomic characterization of hepatitis C virus isolates from Argentina.
J Med Virol
; 47(1): 97-104, 1995 Sep.
Article
em En
| MEDLINE
| ID: mdl-8551267
Thirty-three Argentinian patients infected with hepatitis C virus (HCV) were studied for viral genotyping. The patients included 10 hemophiliac and 4 polytransfused children and 19 adults: 3 polytransfused, 7 dialyzed and 9 sporadic cases. Core-based genotyping permitted the classification of 31 samples. Genotypes II, I and V were the most frequent: 21 (63.6%), 16 (48.4%) and 10 (30.3%) of the 33 patients, respectively. Only one polytransfused patient carried genotype IV. Genotype II was detected in 7 out of 9 sporadic cases. Thirteen patients (39.3%) were coinfected with two genotypes, and 2 others were coinfected with three genotypes. The remaining 2 samples which could not be typed were characterized following the restriction fragment length polymorphism (RFLP) method, and were classified as type 1. One of these had two consecutive transitional mutations in the 5' untranslated region (5' UTR).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Viral
/
Hepatite C
/
Hepacivirus
Limite:
Adult
/
Child
/
Humans
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Estados Unidos