The effects of nomegestrol acetate subdermal implant (Uniplant) on carbohydrate metabolism, serum lipoproteins and on hepatic function in women.
Contraception
; 52(2): 111-4, 1995 Aug.
Article
em En
| MEDLINE
| ID: mdl-8536447
ABSTRACT
PIP: Possible variations in body weight, blood pressure, fasting glucose, HbA1C (glycosylated hemoglobin), insulin, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides, serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), GGT, and bilirubin were assessed for 2 years. 18 healthy female volunteers with a mean age of 23.0 years and mean parity of 0.9 used a single subdermal Silastic implant (Uniplant) containing 55 mg (10%) of nomegestrol acetate. Fasting blood samples were drawn twice prior to implant insertion and then at the 1st, 3rd, 6th, and 12th months and every 6 months thereafter. Body weight increased from 54.9 kg at admission to 55.3 kg at 12 months of use (p 0.05) and to 56.0 kg at 24 months of use. Both systolic and diastolic blood pressure increased slightly at month 12 (p 0.01). Insulin, HbA1C, LDL-C, and GGT remained unchanged during 24 months of Uniplant use. A significant decrease in total cholesterol (p 0.05) was observed in the 3rd month, while a significant decrease in HDL-C (p 0.01) was observed only in the 6th month of Uniplant use. A significant increase in triglycerides (p 0.05) was observed only in the 12th month. Significant increases in fasting blood glucose levels (p 0.05 and p 0.01) were observed in the 3rd and 6th month, respectively, for 24 months of Uniplant use. Significant decreases in SGOT (p 0.05, p 0.01 and p 0.05) were observed in the 6th, 18th, and 24th months, respectively. A significant decrease in SGPT (p 0.05) was observed in the 18th month of Uniplant use. A significant increase in bilirubin (p 0.05) was observed only in the 3rd month of Uniplant use. Within the normal range, variation of fasting glucose was not correlated with changes in insulin levels and no clinical effects on lipoproteins, carbohydrate metabolism, insulin levels, and on hepatic function were observed in these women.
Palavras-chave
Americas; Biology; Blood Pressure--changes; Body Weight--changes; Brazil; Carbohydrate Metabolic Effects; Cholesterol--changes; Clinical Research; Clinical Trials; Contraception; Contraceptive Implants; Contraceptive Methods; Developing Countries; Endocrine System; Family Planning; Hemic System; Hepatic Effects; Hormones; Latin America; Lipids; Metabolic Effects; Physiology; Progestational Hormones; Progesterone; Research Methodology; Research Report; South America
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Congêneres da Progesterona
/
Metabolismo dos Carboidratos
/
Lipoproteínas
/
Fígado
/
Megestrol
Limite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos