Topical treatment of cutaneous leishmaniasis in Belize: in vitro and in vivo studies with Leishmania mexicana.
Int J Parasitol
; 23(1): 121-7, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8468127
Strains of Leishmania mexicana isolated from Belizian patients were found to be highly susceptible to paromomycin sulphate (PR) treatment. This drug at 100 micrograms ml-1 destroyed 85-99.5% of in vitro cultivated Leishmania promastigotes within 4 days of exposure to the drug. Leishmania promastigotes inoculated into the base of the tail of Balb/c mice caused the development of local lesions several weeks after infection. These lesions were totally cleared of parasites after 20 days of topical treatment with PR ointment, comprised of 15% paromomycin sulphate and 12% methylbenzethonium chloride in soft white paraffin. Similar results were also obtained with L. braziliensis infections. Isoenzyme analysis was found to be the method of choice for parasite strain identification. Excreted factor serotyping was only partially effective and promastigote agglutination gave negative results.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leishmania mexicana
/
Paromomicina
/
Leishmaniose Cutânea
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
País/Região como assunto:
America central
/
Belice
/
Caribe ingles
/
Mexico
Idioma:
En
Revista:
Int J Parasitol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Israel
País de publicação:
Reino Unido