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Topical treatment of cutaneous leishmaniasis in Belize: in vitro and in vivo studies with Leishmania mexicana.
el-On, J; Cawich, F; Evans, D A; Weinrauch, L.
Afiliação
  • el-On J; Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Int J Parasitol ; 23(1): 121-7, 1993 Feb.
Article em En | MEDLINE | ID: mdl-8468127
Strains of Leishmania mexicana isolated from Belizian patients were found to be highly susceptible to paromomycin sulphate (PR) treatment. This drug at 100 micrograms ml-1 destroyed 85-99.5% of in vitro cultivated Leishmania promastigotes within 4 days of exposure to the drug. Leishmania promastigotes inoculated into the base of the tail of Balb/c mice caused the development of local lesions several weeks after infection. These lesions were totally cleared of parasites after 20 days of topical treatment with PR ointment, comprised of 15% paromomycin sulphate and 12% methylbenzethonium chloride in soft white paraffin. Similar results were also obtained with L. braziliensis infections. Isoenzyme analysis was found to be the method of choice for parasite strain identification. Excreted factor serotyping was only partially effective and promastigote agglutination gave negative results.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmania mexicana / Paromomicina / Leishmaniose Cutânea Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male País/Região como assunto: America central / Belice / Caribe ingles / Mexico Idioma: En Revista: Int J Parasitol Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Israel País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leishmania mexicana / Paromomicina / Leishmaniose Cutânea Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male País/Região como assunto: America central / Belice / Caribe ingles / Mexico Idioma: En Revista: Int J Parasitol Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Israel País de publicação: Reino Unido