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Cefetamet pivoxil in otitis media.
Quevedo, A; Sossouhounto, R; Kissling, M.
Afiliação
  • Quevedo A; Posto de Urgencia, Rio de Janeiro, Brazil.
Article em En | MEDLINE | ID: mdl-8446394
In this multicentre, open, randomized, parallel-group study, 270 children with acute otitis media aged between 1 and 15 years were randomized to receive either cefetamet pivoxil 10 mg/kg b.i.d. for 7 days (n = 134) or cefaclor 13.5 mg/kg t.i.d. for 7 days (n = 136). At the end of treatment, bacteriological cure occurred in 44/44 (100%) patients receiving cefetamet pivoxil and 24/28 (86%) patients receiving cefaclor. Clinical cure or improvement was experienced by 117/121 (97%) of patients receiving cefetamet pivoxil and 104/115 (90%) patients in the cefaclor group. Adverse side effects, mainly gastrointestinal disorders, occurred in 11% of patients in the cefetamet pivoxil group compared with 15% of patients in the cefaclor group. All adverse events were of mild or moderate severity and subsided rapidly after treatment. Premature treatment withdrawals occurred in 0.7% of patients who received cefetamet pivoxil and in 2.2% of those who received cefaclor.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Otite Média / Ceftizoxima / Cefaclor Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: ORL J Otorhinolaryngol Relat Spec Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Otite Média / Ceftizoxima / Cefaclor Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: ORL J Otorhinolaryngol Relat Spec Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça