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Polyamines in Trypanosoma cruzi.
Schwarcz de Tarlovsky, M N; Hernandez, S M; Bedoya, A M; Lammel, E M; Isola, E L.
Afiliação
  • Schwarcz de Tarlovsky MN; Departamento de Bioquimica, Facultad de Medicina, Universidad de Bs. As., Argentina.
Biochem Mol Biol Int ; 30(3): 547-58, 1993 Jul.
Article em En | MEDLINE | ID: mdl-8401312
Growth and polyamine content of epimastigotes of Trypanosoma cruzi were studied in the presence of precursors or inhibitors of putrescine synthesis. Arginine and agmatine turned out to be better precursors than ornithine. alpha-D-difluoromethylarginine, an inhibitor of arginine decarboxylase, inhibited cellular proliferation and decreased putrescine, spermidine and spermine contents while that of cadaverine remained unchanged. These effects were reversed both by agmatine and putrescine. alpha-D-difluoromethylornithine, an inhibitor of ornithine decarboxylase did not inhibit growth of parasites grown in a polyamine free medium. These results suggest that epimastigotes need polyamines to grow, and that the parasite are able to synthesize them mainly through the arginine decarboxylase pathway.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliaminas / Trypanosoma cruzi Limite: Animals Idioma: En Revista: Biochem Mol Biol Int Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Buscar no Google
Adicionar na Minha BVS
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PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliaminas / Trypanosoma cruzi Limite: Animals Idioma: En Revista: Biochem Mol Biol Int Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido