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Relationship between factors influencing Na(+)-K(+)-ATPase activity and eicosanoid production from 14C-arachidonic acid in spayed rat uterus.
Franchi, A M; Motta, A; Gimeno, A L; Gimeno, M A.
Afiliação
  • Franchi AM; Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Article em En | MEDLINE | ID: mdl-8385780
Na(+)-K(+)-ATPase activity has been implicated in the metabolism of arachidonate and the release of prostaglandins (PG). The aim of the present study was to investigate a potential interaction between the activity of this enzyme and the production of bisenoic PG by uteri isolated from spayed rats. Ouabain or the incubation in low K+ medium (conditions which inhibit Na(+)-K(+)-ATPase) diminished the conversion of 14C-arachidonic acid to 6-keto-PGF1 alpha and PGF2 alpha and increased the production of TXB2. The incubation of uterine strips in a high K+ medium (condition which enhances Na(+)-K(+)-ATPase activity) increased the formation and release of 6-keto-PGF1 alpha and PGF2 alpha while the production of TXB2 and PGF2 diminished significantly. These observations suggested that the activity of Na(+)-K(+)-ATPase could modulate the production of PG and that could be involved in the alterations of the metabolism of eicosanoids found in several tissues during diabetes.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Útero / Eicosanoides / ATPase Trocadora de Sódio-Potássio Limite: Animals Idioma: En Revista: Prostaglandins Leukot Essent Fatty Acids Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Útero / Eicosanoides / ATPase Trocadora de Sódio-Potássio Limite: Animals Idioma: En Revista: Prostaglandins Leukot Essent Fatty Acids Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido