Relationship between factors influencing Na(+)-K(+)-ATPase activity and eicosanoid production from 14C-arachidonic acid in spayed rat uterus.
Prostaglandins Leukot Essent Fatty Acids
; 48(3): 273-5, 1993 Mar.
Article
em En
| MEDLINE
| ID: mdl-8385780
Na(+)-K(+)-ATPase activity has been implicated in the metabolism of arachidonate and the release of prostaglandins (PG). The aim of the present study was to investigate a potential interaction between the activity of this enzyme and the production of bisenoic PG by uteri isolated from spayed rats. Ouabain or the incubation in low K+ medium (conditions which inhibit Na(+)-K(+)-ATPase) diminished the conversion of 14C-arachidonic acid to 6-keto-PGF1 alpha and PGF2 alpha and increased the production of TXB2. The incubation of uterine strips in a high K+ medium (condition which enhances Na(+)-K(+)-ATPase activity) increased the formation and release of 6-keto-PGF1 alpha and PGF2 alpha while the production of TXB2 and PGF2 diminished significantly. These observations suggested that the activity of Na(+)-K(+)-ATPase could modulate the production of PG and that could be involved in the alterations of the metabolism of eicosanoids found in several tissues during diabetes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Útero
/
Eicosanoides
/
ATPase Trocadora de Sódio-Potássio
Limite:
Animals
Idioma:
En
Revista:
Prostaglandins Leukot Essent Fatty Acids
Assunto da revista:
ENDOCRINOLOGIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Reino Unido