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Renal response to amino acid infusion in essential hypertension.
Juncos, L; Cornejo, J C; Pamies-Andreu, E; Romero, J C.
Afiliação
  • Juncos L; Instituto Privado de Especialidades Medicas, Argentina.
Hypertension ; 23(1 Suppl): I225-30, 1994 Jan.
Article em En | MEDLINE | ID: mdl-8282364
In the present study, we evaluated the renal response to a 4-hour infusion of amino acids in essential hypertensive patients, as well as the effects that dietary sodium restriction and enalapril (a converting enzyme inhibitor) had on this renal response. During normal sodium intake, amino acid infusion significantly increased renal plasma flow from 383 +/- 58 to 478 +/- 51 mL/min and glomerular filtration rate from 82 +/- 8 to 100 +/- 13 mL/min. All these effects were abolished when the patients received a low sodium diet (40 mmol/d) for 3 days before the amino acid infusion. The administration of enalapril to the patients during sodium restriction restored the amino acid-induced increment in renal plasma flow (from 388 +/- 35 to 573 +/- 48 mL/min) and glomerular filtration rate (from 88 +/- 9 to 103 +/- 10 mL/min). Mean arterial pressure remained unaltered under all experimental conditions. The results show that in patients with essential hypertension dietary sodium restriction prevents amino acid-induced increments in glomerular filtration rate and renal plasma flow and that this effect is restored during the simultaneous administration of enalapril.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Enalapril / Aminoácidos / Hipertensão / Rim Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertension Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Enalapril / Aminoácidos / Hipertensão / Rim Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertension Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos