Diffusion versus iontophoresis in the transport of gentamicin in the burned rabbit ear model.
Plast Reconstr Surg
; 92(7): 1342-9; discussion 1350-1, 1993 Dec.
Article
em En
| MEDLINE
| ID: mdl-8248410
This experimental study demonstrates that iontophoresis can be used to transport biologically active gentamicin into auricular cartilage. Fifty female New Zealand White rabbits were divided into three groups: live controls with unburned ears, live animals with burn-injured ears (deep or partial-thickness), and euthanized animals with unburned ears. Each group was then divided into subgroups that received gentamicin transported by iontophoresis or diffusion. In ears subjected to iontophoresis, adequate gentamicin activity could be demonstrated only in the cartilage of euthanized animals with unburned ears and live animals with full-thickness burned ears. Diffusion did not transport a detectable level of gentamicin in any instance. Diffusion is ineffective in the transport of gentamicin and should not be used as a primary method of treatment for ear chondritis. Iontophoresis did not transport active gentamicin across partial-thickness burns, presumably because the migrating antibiotic molecules were dispersed throughout the body by the circulation. However, if the circulation is destroyed, as in a full-thickness burn, iontophoresis can move the biologically active gentamicin into the cartilage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queimaduras
/
Gentamicinas
/
Orelha Externa
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Plast Reconstr Surg
Ano de publicação:
1993
Tipo de documento:
Article
País de publicação:
Estados Unidos