[Nucleolar organizer regions in uterine cervical cancer and its precursor epithelial lesions]. / Regiones del organizador nucleolar en cancer de cuello uterino y sus lesiones epiteliales precursoras.
Rev Med Chil
; 121(10): 1110-7, 1993 Oct.
Article
em Es
| MEDLINE
| ID: mdl-8191113
The number of nucleolar organizer regions was assessed in 115 histological samples of uterine cervical carcinoma or precursor epithelial lesions. Normal endocervical or exocervical epithelial tissues were used as controls. Nucleolar organizer regions were stained with colloidal silver in formalin fixed histological samples and quantified in 100 cells, according to Crocker's method. The mean number of nucleolar organizer regions were 13.7 in infiltrative carcinoma, 9.15 in carcinoma in situ, 9.3 in severe dysplasia, 8.4 in moderate dysplasia, 7.5 in mild dysplasia, 6.4 in condylomas and 3.2 and 2.9 in normal exocervical and endocervical epithelia respectively. There were significant differences in the number of nucleolar organizer regions between normal and abnormal tissues and between the different lesions except between moderate and mild dysplasia and between carcinoma in situ and moderate and severe dysplasia. The highest number of nucleolar organizer lesions was always observed in the basal strata of both normal and abnormal tissues. It is concluded that nucleolar organizer regions are a good index of cellular proliferation in uterine epidermoid cervical carcinoma and its precursor lesions, and have a diagnostic value in infiltrative carcinoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Neoplasias do Colo do Útero
/
Região Organizadora do Nucléolo
Limite:
Female
/
Humans
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Chile