Cardiovascular effects produced by micro-injection of angiotensin-(1-7) on vasopressor and vasodepressor sites of the ventrolateral medulla.
Brain Res
; 613(2): 321-5, 1993 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-8186985
In this study, we determined the cardiovascular effects produced by micro-injection of the heptapeptide Angiotensin-(1-7) [Ang-(1-7)] into the rat ventrolateral medulla (VLM). Micro-injection of Ang-(1-7) into the rostral VLM and the caudal pressor area of the VLM produced significant increases in arterial pressure, comparable to that observed with micro-injection of Ang II. The changes in arterial pressure were associated with more variable changes in heart rate (HR) (usually tachycardia). On the other hand, micro-injection of Ang-(1-7) into the caudal depressor area induced decreases in arterial pressure and HR. The results suggest that, besides Ang II, Ang-(1-7) is involved in the mediation of the cardiovascular actions of the renin-angiotensin system in the VLM.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Pressão Sanguínea
/
Angiotensina II
/
Bulbo
/
Frequência Cardíaca
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda