Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus.
Vaccine
; 12(7): 620-4, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-8085379
The T-helper (Th) cell immune response following immunization of C3H (H-2k) mice with a recombinant vaccinia (VAC) virus (TC-5A) expressing the structural proteins (capsid, E1 and E2) of the attenuated vaccine strain (TC-83) of Venezuelan equine encephalitis (VEE) virus was compared with the immune response induced in mice after immunization with TC-83 virus. TC-5A virus elicited Th cells that strongly recognized both VAC and TC-83 viruses in in vitro lymphoblastogenesis tests. Th-cell activation was associated with elevated levels of interleukin-2. TC-5A virus induced long-term humoral immunity; VEE virus-binding and neutralizing antibodies were detected in mouse sera collected from mice 16 months after a single immunization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sindbis virus
/
Vaccinia virus
/
Vacinas Virais
/
Vacinas Sintéticas
/
Linfócitos T Auxiliares-Indutores
/
Vírus da Encefalite Equina Venezuelana
Limite:
Animals
País/Região como assunto:
America do sul
/
Venezuela
Idioma:
En
Revista:
Vaccine
Ano de publicação:
1994
Tipo de documento:
Article
País de publicação:
Holanda