Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations.
J Ethnopharmacol
; 43(1): 1-8, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-7967644
The effects of garlic (Allium sativum L., Liliaceae) dialysate were studied on arrhythmias induced in anaesthetized dogs and on isolated left rat atria. Garlic dialysate suppressed premature ventricular contractions (PVC) and ventricular tachycardia (VT) in ouabain-intoxicated dogs as well as the ectopic rhythms induced by isoprenaline (10(-6) M) and aconitine (10(-8) M) on electrically driven left rat atria. The effective refractory period (ERP) and the sinus node recovery time (SNRT) of isolated rat atria were prolonged in a dose-dependent manner by the administration of this extract. Garlic dialysate decreased the positive inotropic and chronotropic effects of isoprenaline in a concentration-dependent manner. These last effects were increased by propranolol. The results suggest that garlic dialysate has a significant antiarrhythmic effect in both ventricular and supraventricular arrhythmias.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Arritmias Cardíacas
/
Alho
/
Átrios do Coração
/
Contração Miocárdica
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Irlanda