Anti-neutrophil cytoplasmic antibodies in children with ulcerative colitis.
J Pediatr
; 125(5 Pt 1): 707-11, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-7965422
Tests that positively identify individuals with ulcerative colitis, distinguishing them from patients with Crohn disease or other causes of colitis, have not been reliable. Genetic predisposition to inflammatory bowel diseases and genetic influence on immune regulation resulted in the clinical evaluation of potential serologic markers. In adults the presence of anti-neutrophil cytoplasmic antibody (ANCA) in serum identifies patients with ulcerative colitis. In this study we demonstrated that high levels of ANCA are present in 83% of children and adolescents with ulcerative colitis. Furthermore, the majority of patients with ulcerative colitis had a perinuclear pattern of these antibodies by indirect immunofluorescence. The combination of a positive ANCA and perinuclear indirect immunofluorescence pattern was 97% specific for ulcerative colitis. We conclude that determination of ANCA is a sensitive and specific clinical test for identification of children and adolescents with ulcerative colitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Imunoglobulina G
/
Colite Ulcerativa
/
Doença de Crohn
/
Citoplasma
/
Neutrófilos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
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Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
1994
Tipo de documento:
Article
País de publicação:
Estados Unidos