Bioavailability of vitamin A in the rat following ingestion of neomycin sulfate or aluminium hydroxide.
Int J Vitam Nutr Res
; 64(2): 98-103, 1994.
Article
em En
| MEDLINE
| ID: mdl-7960498
The objective of the present paper was to study the interaction of Neomycin and aluminium hydroxide with vitamin A in terms of the effect of these drugs on the bioavailability of vitamin A in the rat. Bioavailability was determined on the basis of the effects of the drugs on growth and on the plasma and hepatic levels of the vitamin. Vitamin A deficient animals were used in assay 1 and normal animals in assay 2. In each assay the animals were divided into 3 groups: one received Neomycin sulfate (0.1% in the diet), the second received aluminium hydroxide (0.05% in the diet) and the third (control) received no drug. Each of these three groups was subdivided into two groups receiving two different concentrations of vitamin A palmitate. The bioavailability of vitamin A was estimated by the parallel line method from the concentration of vitamin A in the diet and in the liver of the animals. No significant differences in growth or plasma retinol levels were observed between the groups of animals studied in assays 1 and 2. Total vitamin A concentration in the liver of the animals which received Neomycin was lower (p < 0.05) than that observed in the controls. Neomycin reduced the bioavailability of vitamin A by 13.9% (maximum, 18.1% and minimum, 9.6%) in assay 1 and by 13.5% (maximum, 17.7% and minimum, 9.3%) in assay 2. Aluminium hydroxide at the level tested did not affect the bioavailability of vitamin A.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina A
/
Neomicina
/
Hidróxido de Alumínio
Limite:
Animals
Idioma:
En
Revista:
Int J Vitam Nutr Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Suíça