Protective effect of ternatin, a flavonoid isolated from Egletes viscosa less., in experimental liver injury.

Rao, V S; Figueiredo, E G; Melo, C L; Viana, G S; Menezes, D B; Matos, M S; Silveira, E R

Rao, V S; Figueiredo, E G; Melo, C L; Viana, G S; Menezes, D B; Matos, M S; Silveira, E R.

Afiliação

Rao VS; Department of Physiology, Federal University of Ceará, Fortaleza, Brazil.

Pharmacology ; 48(6): 392-7, 1994 Jun.

Article em En | MEDLINE | ID: mdl-7914024

RESUMO

The effect of ternatin, a tetramethoxyflavone from Egletes viscosa Less., on liver injury induced by carbon tetrachloride (CCl4) was investigated in rats. Twenty-four hours following CCl4 insult (2.5 ml/kg s.c.), changes in the serum enzymes, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase, as well as liver cell histology were used as indices of hepatic dysfunction. The results show that ternatin (30 mg/kg i.p. daily for 5 consecutive days) causes marked inhibition of CCl4-induced serum enzymes and morbid histologic changes. The observation suggests that ternatin possesses antihepatotoxic activity.

Assuntos

Flavonoides/farmacologia; Fígado/efeitos dos fármacos; Plantas Medicinais; Alanina Transaminase/metabolismo; Animais; Aspartato Aminotransferases/metabolismo; Tetracloreto de Carbono/farmacologia; Masculino; Extratos Vegetais; Ratos; Ratos Wistar; gama-Glutamiltransferase/metabolismo

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Flavonoides / Fígado Limite: Animals Idioma: En Revista: Pharmacology Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

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