AZT-induction of micronuclei in human lymphocyte subpopulations.

Stern, M; Cid, M G; Larripa, I; Slavutsky, I

Stern, M; Cid, M G; Larripa, I; Slavutsky, I.

Afiliação

Stern M; Departamento de Citogenética, Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina, Buenos Aires, Argentina.

Toxicol Lett ; 70(2): 235-42, 1994 Feb 01.

Article em En | MEDLINE | ID: mdl-7905210

RESUMO

Micronucleus (MN) induction by azidothymidine (AZT) in B and T lymphocytes was analyzed by a recently developed MAC (morphology-antibody-chromosome) method which allows the immunologic identification of different cell lineages. An increased frequency of MN in AZT-treated cultures compared with controls was observed. CD4 cells were found to be more sensitive to AZT damage. AZT-treated cultures showed a significant decrease in the proportion of CD4 interphasic cells. Furthermore, higher MN frequencies in isolated lymphocytes than in whole blood in both control and AZT-treated cultures were observed.

Assuntos

Linfócitos B/efeitos dos fármacos; Linfócitos T/efeitos dos fármacos; Zidovudina/toxicidade; Adulto; Linfócitos T CD4-Positivos/efeitos dos fármacos; Células Cultivadas; Feminino; Humanos; Masculino; Testes para Micronúcleos; Pessoa de Meia-Idade

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Zidovudina Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Toxicol Lett Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda

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