[Regression of left ventricular hypertrophy in essential arterial hypertension]. / Reversión de la hipertrofia ventricular izquierda en la hipertensión arterial esencial.
Rev Med Chil
; 122(3): 333-8, 1994 Mar.
Article
em Es
| MEDLINE
| ID: mdl-7809527
The classic concept of a direct pathogenic relationship between high blood pressure and development of left ventricular hypertrophy has been challenged by observations such as the modest correlations between blood pressure and magnitude of left ventricular hypertrophy, its frequent reversal with some antihypertensive medications and its experimental prevention with low doses of an angiotensin-converting enzyme inhibitor that do not modify blood pressure. This evidence has prompted the revision of mechanisms or factors involved in the development of left ventricular hypertrophy. The roles of sympathetic nervous and renin-angiotensin systems, genetic and endothelial factors, are reviewed in this article. It is concluded that blood pressure is not the sole responsible for left ventricular hypertrophy, but an epiphenomenon of one or more local or tissular mechanisms, primary or unchained by an unknown genetic factor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipertrofia Ventricular Esquerda
Limite:
Animals
/
Humans
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
1994
Tipo de documento:
Article
País de publicação:
Chile