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Cefetamet pivoxil in the treatment of uncomplicated gonorrhea.
Lucena, R; Borges, C E; Vieiralves, L F; Kanga, J M; Hohl, P; Zappelini, M; Kissling, M.
Afiliação
  • Lucena R; Public Institution-Urology, Clinical Urogynecologists Association, Rio de Janeiro, Brazil.
Diagn Microbiol Infect Dis ; 19(2): 121-7, 1994 Jun.
Article em En | MEDLINE | ID: mdl-7805356
We studied the efficacy and safety of cefetamet pivoxil (CAT), an oral aminothiazolyl cephalosporin, in a series of open, comparative multicenter studies in 207 women (four study centers) with uncomplicated gonorrhea, and summarized and pooled the results with those of earlier open dose-finding trials (360 men; six study centers). We compared single-dose treatment regimen of CAT--over the range of 400-1500 mg--with spectinomycin, thiamphenicol, ampicillin, or amoxicillin plus probenecid. The overall cure rates were 100% in 88 women treated with 1500 mg CAT and in 137 men treated with 1200 or 1500 mg CAT, 98% (114 of 116 men) in those treated with 800 or 1000 mg CAT, and 93% (42 of 45 men) in those treated with 400 or 500 mg CAT; the composite cure rate of the comparators was 97%. The tolerability of CAT (n = 428) compared favorably (1.8% adverse events) with that of the standard drugs (n = 139) (4.3% adverse events). Single-dose treatment with 1500 mg CAT is effective and safe in adults with uncomplicated gonorrhea.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceftizoxima / Gonorreia Tipo de estudo: Clinical_trials / Observational_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Diagn Microbiol Infect Dis Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceftizoxima / Gonorreia Tipo de estudo: Clinical_trials / Observational_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Diagn Microbiol Infect Dis Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos