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Repeated intracerebroventricular administration of taurine lowers LH levels and postpones vaginal opening in peripubertal female rats.
Arias, P; Feleder, C; Rodríguez, M; Ginzburg, M; Refojo, D; Szwarcfarb, B; Moguilevsky, J A.
Afiliação
  • Arias P; Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Brain Res Dev Brain Res ; 85(1): 137-9, 1995 Mar 16.
Article em En | MEDLINE | ID: mdl-7781160
UNLABELLED: We investigated the effect of repeated intracerebroventricular injections of taurine (Tau, 0.15 mumol/3 microliters distilled water), administered during postnatal days 23-29, on serum LH levels, and on the hypothalamic content of LHRH and amino acid neurotransmitters (measured by HPLC and electrochemical detection) in 30-day-old female rats (n = 18). Treatment with Tau lowered serum LH (Tau: 0.20 +/- 0.04; CONTROLS: 1.04 +/- 0.21 ng/ml RP3; mean +/- S.E.M.; P < 0.05) as well as hypothalamic LHRH levels (Tau: 82.6 +/- 9.5; controls: 128.7 +/- 14.1 pg/mg wet tissue, P < 0.05). Tau treatment doubled hypothalamic GABA levels (Tau: 31.3 +/- 2.9; CONTROLS: 15.6 +/- 1.2 nmoles/mg wet tissue, P < 0.001). In a second group of animals (n = 13), Tau treatment delayed vaginal opening by more than 2 days (P < 0.05 vs. controls). It is concluded that supplementation with Tau during the fourth postnatal week reduces LHRH/LH secretion and postpones sexual development, perhaps by increasing the activity of the hypothalamic GABAergic system.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maturidade Sexual / Taurina / Vagina / Hormônio Luteinizante / Ratos Wistar Limite: Animals Idioma: En Revista: Brain Res Dev Brain Res Assunto da revista: CEREBRO / NEUROLOGIA Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Maturidade Sexual / Taurina / Vagina / Hormônio Luteinizante / Ratos Wistar Limite: Animals Idioma: En Revista: Brain Res Dev Brain Res Assunto da revista: CEREBRO / NEUROLOGIA Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda