Synthetic inhibitors of tissue kallikrein: effects in vivo in a model of allergic inflammation.
Braz J Med Biol Res
; 27(8): 1943-7, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7749385
We have recently developed synthetic low molecular weight inhibitors of both tissue and plasma kallikreins. Several of these were evaluated in vivo in the ovalbumin-sensitised guinea pig for their ability to prevent the bronchoconstriction elicited by antigen challenge. The selective tissue kallikrein inhibitor CH-694 (but not the selective plasma kallikrein inhibitor CH-684) caused highly significant falls in airways resistance when it was administered at 10 mg/kg intraperitoneally 15 min before and 90 min after challenge. There was also a highly significant fall in the tissue kallikrein activity measured in broncho-alveolar lavage fluid. Inhibitors of tissue kallikrein may prove effective in the treatment of allergic inflammation in man.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calicreínas
/
Hipersensibilidade
/
Inflamação
/
Cetonas
Limite:
Animals
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
1994
Tipo de documento:
Article
País de publicação:
Brasil