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Synthetic inhibitors of tissue kallikrein: effects in vivo in a model of allergic inflammation.
Szelke, M; Evans, D M; Jones, D M; Fawcett, L; Ashworth, D; Olsson, H; Featherstone, R L; Church, M K.
Afiliação
  • Szelke M; Ferring Research Institute, University of Southampton Research Centre, Chilworth, UK.
Braz J Med Biol Res ; 27(8): 1943-7, 1994 Aug.
Article em En | MEDLINE | ID: mdl-7749385
We have recently developed synthetic low molecular weight inhibitors of both tissue and plasma kallikreins. Several of these were evaluated in vivo in the ovalbumin-sensitised guinea pig for their ability to prevent the bronchoconstriction elicited by antigen challenge. The selective tissue kallikrein inhibitor CH-694 (but not the selective plasma kallikrein inhibitor CH-684) caused highly significant falls in airways resistance when it was administered at 10 mg/kg intraperitoneally 15 min before and 90 min after challenge. There was also a highly significant fall in the tissue kallikrein activity measured in broncho-alveolar lavage fluid. Inhibitors of tissue kallikrein may prove effective in the treatment of allergic inflammation in man.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calicreínas / Hipersensibilidade / Inflamação / Cetonas Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 1994 Tipo de documento: Article País de publicação: Brasil
Buscar no Google
Adicionar na Minha BVS
Imprimir
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PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calicreínas / Hipersensibilidade / Inflamação / Cetonas Limite: Animals Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 1994 Tipo de documento: Article País de publicação: Brasil