Resistance of Shigella dysenteriae type 1 to ampicillin and other antimicrobial agents: strains isolated during a dysentery outbreak in a hospital in Mexico City.
J Infect Dis
; 133(5): 572-5, 1976 May.
Article
em En
| MEDLINE
| ID: mdl-772132
In June 1972, an epidemic of dysentery began in a hospital ward lodging 22 children with tuberculosis. Fifteen of them developed the disease and five children died. The age of the children ranged from five months to four years. A rectal swab culture taken from all hospitalized children three weeks after the initiation of the outbreak revealed Shigella dysenteriae type 1 in five of the patients (28%). The strains isolated were susceptible to cephalothin, gentamicin, kanamycin, colistin, trimethoprim, and nalidixic acid, but were resistant to ampicillin (greater than 5,000 mug/ml), chloramphenicol (300 mug/ml), streptomycin (400 mug/ml), tetracycline (100 mug/ml), and sulfadiazine (1,000 mug per disk). Transfer experiments to Escherichia coli K-12 indicated that these strains were infected with two different plasmids; one was responsible for resistance to chloramphenicol, tetracycline, streptomycin, and sulfonamides, and the other caused resistance to ampicillin. The epidemiological and clinical importance of these findings is emphasized.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Shigella dysenteriae
/
Disenteria Bacilar
/
Ampicilina
Limite:
Child, preschool
/
Humans
/
Infant
País/Região como assunto:
Mexico
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
1976
Tipo de documento:
Article
País de publicação:
Estados Unidos