Reinforcing properties of fencamfamine: involvement of dopamine and opioid receptors.
Pharmacol Biochem Behav
; 50(1): 35-40, 1995 Jan.
Article
em En
| MEDLINE
| ID: mdl-7700952
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had been determined, animals were conditioned with FCF (1.75, 3.5, or 7.0 mg/kg; IP). Only at the dose of 3.5 mg/kg FCF produced a significant place preference. Pretreatment with SCH23390 (0.05 mg/kg; SC) or naloxone (1.0 mg/kg; SC) 10 min before FCF (3.5 mg/kg, IP) blocked both FCF-induced hyperactivity and CPP. Pretreatment with metoclopramide (10.0 mg/kg; IP) or pimozide (1.0 mg/kg, IP), respectively, 30 min or 4 h before FCF (3.5 mg/kg; IP), which blocked the FCF-induced locomotor activity, failed to influence place conditioning produced by FCF. In conclusion, the present study suggests that dopamine D1 and opioid receptors are related to FCF reinforcing effect, while dopamine D2 subtype receptor was ineffective in modifying FCF-induced CPP.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reforço Psicológico
/
Receptores de Dopamina D1
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Receptores Opioides mu
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Antagonistas dos Receptores de Dopamina D2
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Estimulantes do Sistema Nervoso Central
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Norbornanos
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos