Biochemically active sesquiterpene lactones from Ratibida mexicana.
Phytochemistry
; 40(2): 419-25, 1995 Sep.
Article
em En
| MEDLINE
| ID: mdl-7546556
Bioactivity-directed fractionation of the methanol extract of the roots of Ratibida mexicana resulted in the isolation of two bioactive sesquiterpene lactones, isoalloalantolactone and elema-1,3,11-trien-8,12-olide. Both compounds caused a significant inhibition of the radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, exerted moderate cytotoxic activity against three different solid tumour cell lines and inhibited significantly the radial growth of three phytopathogenic fungi. Isoalloalantolactone also caused the inhibition of ATP synthesis, proton uptake and electron transport (basal, phosphorylating and uncoupled) from water to methylviologen, therefore acting as a Hill's reaction inhibitor. The lactone did not affect photosystem I but inhibited photosystem II. The site of inhibition of isoalloalantolactone is located in the span of P680 to QA redox enzymes because the uncoupled electron transport from water to silicomolybdate and, from DPC to DCIP are inhibited approximately to the same extent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Sesquiterpenos
/
Magnoliopsida
/
Lactonas
/
Antifúngicos
/
Antineoplásicos Fitogênicos
Limite:
Humans
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
1995
Tipo de documento:
Article
País de publicação:
Reino Unido