2'-Fluoropolynucleotide-directed reverse transcriptase reactions. Effect of homologous polynucleotides.
J Enzyme Inhib
; 8(4): 261-5, 1995.
Article
em En
| MEDLINE
| ID: mdl-7542323
Several homologous polynucleotides have been tested as inhibitors on the reactions catalyzed by avian myeloblastosis virus (AMV) reverse transcriptase, in the presence of polyribonucleotides and 2'-fluorinated polynucleotides as templates. Polynucleotides differentially inhibited the reactions catalyzed by reverse transcriptase in the presence of these synthetic templates. Polyriboadenylic acid (poly(rA), poly(2'-O-methyladenylic acid) (poly(Am)), poly(2'-fluoro-2'-deoxyadenylic acid) (poly(dAfl), polyinosinic acid (poly(rI)) and polyuridylic acid poly(rU)) inhibited the polyribonucleotide-, but not the 2'-fluorinated polynucleotide-directed reverse transcriptase activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polidesoxirribonucleotídeos
/
Polinucleotídeos
/
Polirribonucleotídeos
/
DNA
/
DNA Polimerase Dirigida por RNA
Idioma:
En
Revista:
J Enzyme Inhib
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Suíça