Human neonatal red blood cells. An experimental model for the study of calcium-activated potassium channel refractoriness.
Arch Int Physiol Biochim Biophys
; 101(5): 297-301, 1993.
Article
em En
| MEDLINE
| ID: mdl-7508289
To study some characteristics of calcium-activated potassium channels free from plasma membrane lipid perturbations, neonatal red blood cells were selected. To this end, cells not previously treated (ATP depletion and/or reversible lysis) were exposed to the ionophore A23187 in a NO3 medium with calcium. The net efflux of potassium from the cells was studied. Preincubation in a medium devoid of potassium induced a significant decrease only in the rate constant of potassium flux. The data suggest that, in the absence of plasma membrane lipid impairment, changes in internal sites reactivity with calcium ions of channel proteins would be involved in the refractoriness. This would be at variance with channel density modifications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Potássio
/
Cálcio
/
Eritrócitos
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
/
Newborn
Idioma:
En
Revista:
Arch Int Physiol Biochim Biophys
Assunto da revista:
BIOFISICA
/
BIOQUIMICA
/
FISIOLOGIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Bélgica