NMDA receptors in NTS are involved in bradycardic but not in pressor response of chemoreflex.
Am J Physiol
; 269(4 Pt 2): H1421-7, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-7485576
Activation of carotid chemoreceptors with intravenous potassium cyanide (KCN) produces increases in arterial pressure, bradycardia, and tachypnea. In the present study, we activated carotid chemoreceptors with KCN and the neurotransmission of the chemoreceptor reflex into the commissural nucleus tractus solitarii (NTS) was blocked with phosphonovaleric acid (AP-5), an N-methyl-D-aspartate (NMDA)-selective antagonist. The aim of this study was to evaluate the involvement of NMDA receptors in the cardiovascular and respiratory responses produced by chemoreceptor activation in unanesthetized rats. The pressor response to KCN was not changed after microinjection of three different doses of AP-5 into the NTS, whereas the bradycardic response was reduced in a dose-dependent manner. The increase in respiratory frequency in response to carotid chemoreceptor activation was also not affected by AP-5 microinjected into the NTS. The data indicate that the activation of the cardiovagal component of the chemoreflex in the commissural NTS is mediated by NMDA receptors, whereas pressor and ventilatory responses are not.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reflexo
/
Pressão Sanguínea
/
Células Quimiorreceptoras
/
Receptores de N-Metil-D-Aspartato
/
Núcleo Solitário
/
Frequência Cardíaca
Limite:
Animals
Idioma:
En
Revista:
Am J Physiol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos