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[Effect of corticosteroids in mucocutaneous leishmaniasis. Experimental study]. / Efecto de los corticosteroides en la leishmaniasis cutáneo-mucosa. Estudio experimental.
Rev Biol Trop ; 28(1): 109-19, 1980 Jul.
Article em Es | MEDLINE | ID: mdl-7465874
Groups of "immunized" and "non-immunized" hamsters were inoculated weekly with 2, 10 or 20 mg of cortisone acetate per 100 gr of body weight and infected with Leishmania mexicana or L. braziliensis. Doses of 10 and 20 mg of cortisone were excessive, since the animals died with bacterial infections before they developed leishmaniasis. Inflammation and necrosis were more evident in animals inoculated with cortisone and L. mexicana. Furthermore, this strain caused lesions in lymphatic ganglia of immunosuppressed animals, but was not observed in those inoculated with L. braziliensis. There was no difference between the pathological findings in nonimmune and immune hamsters. These results could indicate that passive immunization with dead antigen is not effective.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cortisona / Leishmaniose Mucocutânea / Leishmania Idioma: Es Revista: Rev Biol Trop Ano de publicação: 1980 Tipo de documento: Article País de publicação: Costa Rica
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cortisona / Leishmaniose Mucocutânea / Leishmania Idioma: Es Revista: Rev Biol Trop Ano de publicação: 1980 Tipo de documento: Article País de publicação: Costa Rica