Effects of the number of DNP groups on dinitrophenylated human serum albumin upon the induction of immunological memory for the dinitrophenyl determinant.
Arch Invest Med (Mex)
; 8(3): 165-74, 1977.
Article
em En
| MEDLINE
| ID: mdl-72549
Immunological memory to the DNP determinant is shown to be a positive correlate of the primary anti-DNP response and of the extent of DNP substitution in the priming antigen. Antigen dose-response curves for immunological memory first increase with antigen dose to reach a maximum and then decrease in the high dose region. Increasing the extent of DNP substitution in the priming antigen shifts the dose-response curves to lower antigen doses and promotes the antigen's ability to induce immunological memory to a level greater than that expected by its ability to induce a primary response. The findings are interpreted in terms of postulated effects of degree of DNP substitution on the binding of antigen to cell receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Albumina Sérica
/
Dinitrobenzenos
/
Memória Imunológica
/
Nitrobenzenos
Limite:
Humans
Idioma:
En
Revista:
Arch Invest Med (Mex)
Ano de publicação:
1977
Tipo de documento:
Article
País de publicação:
México