Nonspecific immunodepression and protective immunity in mice infected with Leishmania mexicana.
Infect Immun
; 32(2): 415-9, 1981 May.
Article
em En
| MEDLINE
| ID: mdl-7019070
C57BL/6 mice infected with Leishmania mexicana showed depression of the in vitro immunoglobulin M-plaque-forming cell response to sheep erythrocytes. Immunodepression was present 3 weeks after inoculation and was maximal at 11 weeks. Thereafter, there was a gradual return to normal immunoresponsiveness correlated with the resolution of lesions. At the time of maximal immunodepression, spleen cells from infected mice diminished the plaque-forming cell response to sheep erythrocytes of normal spleen cells. On the other hand, specific responses, as exemplified by protective immunity to a challenge infection and delayed hypersensitivity responses to parasite antigens, were apparently unaffected. These responses were both present in mice bearing primary lesions and were maximal in recovered mice. The significance of these findings is discussed in relation to a current hypothesis on parasite-induced immunodepression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leishmaniose
/
Hipersensibilidade Tardia
/
Tolerância Imunológica
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Formação de Anticorpos
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
1981
Tipo de documento:
Article
País de publicação:
Estados Unidos