[Simultaneous determination of 4 anticonvulsant drugs by high pressure liquid chromatography (HPLC)]. / Determinação simultânea de quatro anticonvulsivantes por cromatografia líquida de alta pressão (HPLC).
Arq Neuropsiquiatr
; 42(3): 203-8, 1984 Sep.
Article
em Pt
| MEDLINE
| ID: mdl-6497712
We describe a sensitive and precise method for the simultaneous high pressure liquid-chromatography determination of phenobarbital, diphenylhydantoin, primidone, and carbamazepine in serum. The drugs are extracted into chloroform, dried and dissolved in the mobile phase. The drugs are eluted from a reverse-phase column with methanol/water and detected by their absorption at 214 nm. Concentrations are estimated from their peak heights. The results, when compared with those by enzyme-immunoassay, gave correlation coefficients of 0.990 for phenobarbital, 0.993 for diphenylhydantoin, 0.992 for primidone and 0.994 for carbamazepine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenobarbital
/
Fenitoína
/
Primidona
/
Carbamazepina
/
Cromatografia Líquida de Alta Pressão
Limite:
Humans
Idioma:
Pt
Revista:
Arq Neuropsiquiatr
Ano de publicação:
1984
Tipo de documento:
Article
País de publicação:
Alemanha