Opportunistic infections and Kaposi's sarcoma among Haitians: evidence of a new acquired immunodeficiency state.

Pitchenik, A E; Fischl, M A; Dickinson, G M; Becker, D M; Fournier, A M; O'Connell, M T; Colton, R M; Spira, T J

Pitchenik, A E; Fischl, M A; Dickinson, G M; Becker, D M; Fournier, A M; O'Connell, M T; Colton, R M; Spira, T J.

Ann Intern Med ; 98(3): 277-84, 1983 Mar.

Article em En | MEDLINE | ID: mdl-6299151

RESUMO

Twenty Haitian patients, hospitalized from 1 April 1980 to 20 June 1982, had Pneumocystis carinii pneumonia, central nervous system toxoplasmosis, esophageal candidiasis, cryptococcosis, disseminated cytomegalovirus, progressive herpes simplex virus, chronic enteric coccidiosis, or invasive Kaposi's sarcoma. Ten patients died. Opportunistic infections were frequently multiple and were recurrent in three patients. In seven patients disseminated tuberculosis preceded the other infections by 2 to 15 months. There was no evidence of an underlying immunosuppressive disease, and no history of homosexuality or intravenous drug abuse. At least three patients probably acquired the syndrome in Haiti. Lymphadenopathy was common. Seventeen patients tested had anergy, and 18 had lymphopenia. Monoclonal antibody analysis of peripheral-blood T-cell subsets done on 11 patients showed a marked decrease in T-helper cells and an inversion of the normal ratio of T-helper cells to T-suppressor cells. This syndrome among heterosexual Haitians is strikingly similar to the syndrome of immunodeficiency described recently among American homosexuals.

Assuntos

Síndrome da Imunodeficiência Adquirida/imunologia; Sarcoma de Kaposi/imunologia; Síndrome da Imunodeficiência Adquirida/complicações; Síndrome da Imunodeficiência Adquirida/epidemiologia; Adulto; Anticorpos Antibacterianos/análise; Anticorpos Antifúngicos/análise; Anticorpos Antivirais/análise; Peso Corporal; Candida/imunologia; Citomegalovirus/imunologia; Comportamento Alimentar; Feminino; Haiti; Herpesvirus Humano 4/imunologia; Humanos; Contagem de Leucócitos; Masculino; Pneumonia por Pneumocystis/complicações; Pneumonia por Pneumocystis/imunologia; Sarcoma de Kaposi/complicações; Sarcoma de Kaposi/epidemiologia; Simplexvirus/imunologia; Dobras Cutâneas; Linfócitos T/imunologia; Toxoplasma/imunologia; Treponema/imunologia

Palavras-chave

Acquired Immunodeficiency Syndrome; Americas; Cancer; Central Nervous System Effects; Cultural Background; Demographic Factors; Developed Countries; Developing Countries; Diseases; Ethnic Groups; Florida; Hiv Infections; Immunological Effects; Neoplasms; Neurologic Effects; North America; Northern America; Population; Population Characteristics; Signs And Symptoms; United States; Viral Diseases

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma de Kaposi / Síndrome da Imunodeficiência Adquirida Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Caribe / Haiti Idioma: En Revista: Ann Intern Med Ano de publicação: 1983 Tipo de documento: Article País de publicação: Estados Unidos

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