Cell cycle regulation in mammalian cells: hormones and commitment to DNA synthesis.
Arch Biol Med Exp
; 12(3): 319-24, 1979 Oct.
Article
em En
| MEDLINE
| ID: mdl-399721
The growth regulation of cultured mouse fibroblasts and functional adrenal cells was studied. Variants of mutants from these cell lines were obtained. The effects of classical hormones (insulin, hydrocortisone and adrenocorticotropin) and of growth factors (EGF and PF) were analysed. These hormones stimulate or inhibit the entry of cells into S phase. However G1 cells become irreversibly committed to DNA synthesis 5 hours before entering S phase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Substâncias de Crescimento
/
Replicação do DNA
/
Hormônios
Limite:
Animals
Idioma:
En
Revista:
Arch Biol Med Exp
Ano de publicação:
1979
Tipo de documento:
Article
País de publicação:
Chile