Hormonal influence on the response of the uterus of the Brazilian marsupial Didelphis albiventris to adrenergic drugs.
Gen Comp Endocrinol
; 58(2): 179-85, 1985 May.
Article
em En
| MEDLINE
| ID: mdl-3996887
The influence of catecholamines on the estrogenized uterus of the Didelphis albiventris was studied in an in vitro preparation. It was observed that the D. albiventris uterus reacts to both alpha and beta-adrenergic agonists but not dopaminergic ones. Adrenaline is more potent in inducing a contractile response than is noradrenaline. Isoprenaline, when added to the bath, is able neither to induce a response nor to interfere with a contraction previously induced by acetylcholine. It is, however, able to block the contractile response brought about by electric field stimulation. In an in vitro preparation from animals previously treated with estrogen and progesterone, the sensitivity to both alpha- and beta-adrenergic drugs was greatly increased. This is demonstrated by a higher pD2 in progesteronized animals compared to that in estrogenized ones. The increased sensitivity to beta-agonists after progesterone treatment is illustrated by the fact that isoprenaline is effective in inducing a relaxation of the uterus, in these conditions. These results indicate that the Brazilian opossum should be included among those animals in which progesterone enhances uterine sensitivity to drugs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gambás
/
Progesterona
/
Contração Uterina
/
Catecolaminas
/
Estradiol
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Gen Comp Endocrinol
Ano de publicação:
1985
Tipo de documento:
Article
País de publicação:
Estados Unidos