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Disposition of intravenously administered pharmacologic doses of vitamin E in newborn rabbits.
J Pediatr ; 108(1): 145-50, 1986 Jan.
Article em En | MEDLINE | ID: mdl-3944681
Newborn rabbits were given a single intravenous dose (100 mg/kg) of either alpha-tocopherol or alpha-tocopheryl acetate to compare disposition characteristics of these two forms of vitamin E. The resulting tissue concentrations of alpha-tocopherol and alpha-tocopheryl acetate differed significantly. Tissue concentrations of either form of vitamin E were much higher than those provided by normal nutrition, and remained unchanged (except in the liver) for 6 days after dose. alpha-Tocopheryl acetate was not completely converted to alpha-tocopherol, and only 50% of the dose was recovered 3 days after administration. The entire dose of alpha-tocopherol was recovered intact 3 days after administration. The persistence of very high tissue vitamin E concentrations after a single intravenous dosing, the disappearance from the body of half of the administered dose of alpha-tocopheryl acetate, and the lack of complete conversion of alpha-tocopheryl acetate to alpha-tocopherol when given intravenously have profound implications regarding the current clinical practice of giving repeated pharmacologic doses of vitamin E to newborn infants.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina E / Alfa-Tocoferol Limite: Animals Idioma: En Revista: J Pediatr Ano de publicação: 1986 Tipo de documento: Article País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina E / Alfa-Tocoferol Limite: Animals Idioma: En Revista: J Pediatr Ano de publicação: 1986 Tipo de documento: Article País de publicação: Estados Unidos