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Effect of Oral Zinc Supplementation on Phase Angle and Bioelectrical Impedance Vector Analysis in Duchenne Muscular Dystrophy: A Non-Randomized Clinical Trial.
Vermeulen-Serpa, Karina Marques; Lopes, Márcia Marilia Gomes Dantas; Alves, Camila Xavier; Grilo, Evellyn Camara; Cunha, Thais Alves; Miranda, Carolinne Thaisa de Oliveira Fernandes; Bezerra, Breno Gustavo Porfirio; Leite-Lais, Lucia; Brandão-Neto, José; Vale, Sancha Helena de Lima.
Afiliação
  • Vermeulen-Serpa KM; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil.
  • Lopes MMGD; Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
  • Alves CX; Nutrition Division, Liga Norte Riograndense Contra o Câncer, Natal 59040-000, RN, Brazil.
  • Grilo EC; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil.
  • Cunha TA; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil.
  • Miranda CTOF; Postgraduate Program in Medicine (Hematology/Oncology), Federal University of São Paulo, São Paulo 04021-001, SP, Brazil.
  • Bezerra BGP; Center for Primary Processing and Reuse of Produced Water and Waste, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
  • Leite-Lais L; Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
  • Brandão-Neto J; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil.
  • Vale SHL; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil.
Nutrients ; 16(19)2024 Sep 29.
Article em En | MEDLINE | ID: mdl-39408270
ABSTRACT
Zinc plays a crucial role in cell structure and functionality. Neurodegenerative Duchenne muscular dystrophy (DMD) alters muscle membrane structure, leading to a loss of muscle mass and strength. The objective of this study was to evaluate the changes in phase angle (PA) and bioelectrical impedance vector analysis (BIVA) results in patients with DMD after oral zinc supplementation. This clinical trial included 33 boys aged 5.6 to 24.5 years diagnosed with DMD. They were divided into three groups according to age (G1, G2, and G3) and supplemented with oral zinc. The mean serum zinc concentration was 74 µg/dL, and 29% of patients had concentrations below the reference value. The baseline values (mean (standard deviation)) of the bioelectrical impedance parameters PA, resistance (R), and reactance (Xc) were 2.59° (0.84°), 924.36 (212.31) Ω, and 39.64 (8.41) Ω, respectively. An increase in R and a decrease in PA and lean mass proportional to age were observed, along with a negative correlation (r = -0.614; p < 0.001) between age and PA. The average cell mass in G1 was greater than that in G3 (p = 0.012). There were no significant differences in serum zinc levels or bioelectrical impedance parameters before and after zinc supplementation. We conclude that this population is at risk of zinc deficiency and the proposed dosage of zinc supplementation was not sufficient to alter serum zinc levels, PA and BIVA results.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zinco / Impedância Elétrica / Suplementos Nutricionais / Distrofia Muscular de Duchenne Limite: Adolescent / Adult / Child / Child, preschool / Humans / Male Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zinco / Impedância Elétrica / Suplementos Nutricionais / Distrofia Muscular de Duchenne Limite: Adolescent / Adult / Child / Child, preschool / Humans / Male Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça