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Fructose-1,6-bisphosphate reverses hypotensive effect caused by L-kynurenine in Wistar male rats.
Catarina, Anderson Velasque; Branchini, Gisele; Caceres, Rafael Andrade; Fernandes, Renata Streck; Costa, Bruna Pasqualotto; Machado, Kleiton Lima De Godoy; Becker, Tiago; Ferreira, Luis Fernando; Rigatto, Katya; de Oliveira, Jarbas Rodrigues; Nunes, Fernanda Bordignon.
Afiliação
  • Catarina AV; Graduate Program in Pathology-Laboratory of Computational, Molecular, and Cellular Biophysics-Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
  • Branchini G; Graduate Program in Pathology-Laboratory of Computational, Molecular, and Cellular Biophysics-Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
  • Caceres RA; Department of Pharmacosciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
  • Fernandes RS; Graduate Program in Health Sciences-Laboratory of Translational Physiology-Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
  • Costa BP; Laboratory of Inflammation and Cellular Biophysics-Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil.
  • Machado KLG; Department of Plant Biology, Universidade Federal de Viçosa (UFV), Viçosa, Brazil.
  • Becker T; Department of Mechanical Engineering, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Ferreira LF; School of Electronics, Electrical Engineering and Computer Sciences, Queen's University of Belfast, Belfast, UK.
  • Rigatto K; Graduate Program in Medicine: Hepatology-Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
  • de Oliveira JR; Graduate Program in Health Sciences-Laboratory of Translational Physiology-Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
  • Nunes FB; Laboratory of Inflammation and Cellular Biophysics-Pontifícia Universidade Católica Do Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil.
Physiol Rep ; 12(19): e70033, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39396923
ABSTRACT
Hypotension is one of the main characteristics of the systemic inflammation, basically caused by endothelial dysfunction. Studies have shown that the amino acid L-kynurenine (KYN) causes vasodilation in mammals, leading to hypotensive shock. In hypotensive shock, when activated by the KYN, the voltage-gated potassium channel encoded by the family KCNQ (Kv7) gene can cause vasodilation. Fructose-1,6-bisphosphate (FBP) it is being considered in studies an anti-inflammatory, antioxidant, immunomodulator, and a modulator of some ion channels (Ca2+, Na+, and K+). We analyzed the effects of KYN and FBP on mean blood pressure (MBP), systolic and diastolic (DBP) blood pressure, and heart rate variability (HRV) in Wistar rats. Results demonstrated that the administration of KYN significant decreased MBP, DBP, and increased HRV. Importantly, the FBP treatment reversed the KYN effects on MBP, DBP, and HRV. Molecular Docking Simulations suggested that KYN and FBP present a very close estimated free energy of binding and the same position into structure of KCNQ4. Our results did demonstrate that FBP blunted the decrease in BP, provoked by KYN. Results raise new hypotheses for future and studies in the treatment of hypotension resulting from inflammation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Ratos Wistar / Frutosedifosfatos / Frequência Cardíaca / Hipotensão / Cinurenina Limite: Animals Idioma: En Revista: Physiol Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Ratos Wistar / Frutosedifosfatos / Frequência Cardíaca / Hipotensão / Cinurenina Limite: Animals Idioma: En Revista: Physiol Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos