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Glucose metabolism in the perfused liver did not improve with resistance training in male Swiss mice under caloric restriction.
Perego Junior, Julio Ernesto; Tomazi Silva, Kauane; Balani Rando, Ana Luiza; Sousa Lima, Mateus; Garcia, Rosângela Fernandes; Pedrosa, Maria Montserrat Diaz.
Afiliação
  • Perego Junior JE; Program of Graduate Studies in Physiological Sciences, State University of Maringá, Maringá, PR, Brazil.
  • Tomazi Silva K; Program of Graduate Studies in Physiological Sciences, State University of Maringá, Maringá, PR, Brazil.
  • Balani Rando AL; Department of Biology, State University of Maringá, Maringá, PR, Brazil.
  • Sousa Lima M; Department of Biology, State University of Maringá, Maringá, PR, Brazil.
  • Garcia RF; Department of Physiological Sciences, State University of Maringá, Maringá, PR, Brazil.
  • Pedrosa MMD; Department of Physiological Sciences, State University of Maringá, Maringá, PR, Brazil.
Arch Physiol Biochem ; : 1-10, 2024 Oct 11.
Article em En | MEDLINE | ID: mdl-39392336
ABSTRACT
CONTEXT Energy homeostasis is a primary factor for the survival of mammals. Many tissues and organs, among which is the liver, keep this homeostasis in varied circumstances, including caloric restriction (CR) and physical activity.

OBJECTIVE:

This study investigated glucose metabolism using the following groups of eight-week-old male Swiss mice CS, sedentary and fed freely; RS, sedentary and RT, trained, both under 30% CR (n = 20-23 per group).

RESULTS:

Organs and fat depots of groups RS and RT were similar to CS, although body weight was lower. CR did not impair training performance nor affected systemic or hepatic glucose metabolism. Training combined with CR (group RT) improved in vivo glucose tolerance and did not affect liver gluconeogenesis.

CONCLUSIONS:

The mice tolerated the prolonged moderate CR without impairment of their well-being, glucose homeostasis, and resistance training performance. But the higher liver gluconeogenic efficiency previously demonstrated using this training protocol in mice was not evidenced under CR.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Arch Physiol Biochem Assunto da revista: BIOQUIMICA / FISIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Arch Physiol Biochem Assunto da revista: BIOQUIMICA / FISIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido