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Neonatal and maternal outcomes of mRNA versus Non-mRNA COVID-19 vaccines in pregnant patients: a systematic review and meta-analysis.
Oliveira, Juliana Almeida; da Silva, Eloisa Gonçalves; Karasu, Ayse Filiz Gokmen; Silva, Anelise Maria Nicolau; Philip, Chris Elizabeth.
Afiliação
  • Oliveira JA; Universidade Federal de Minas Gerais Belo HorizonteMG Brazil Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • da Silva EG; Centro Universitário de Jaguariúna JaguariúnaSP Brazil Centro Universitário de Jaguariúna, Jaguariúna, SP, Brazil.
  • Karasu AFG; Bezmialem Vakif University Istanbul Turkey Obstetrician and Gynecologist, Bezmialem Vakif University, Istanbul, Turkey.
  • Silva AMN; Escola Bahiana de Medicina e Saúde Pública SalvadorBA Brazil Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.
  • Philip CE; Beaumont hospital Dublin Ireland Obstetrician and Gynecologist, Beaumont hospital, Dublin, Ireland.
Rev Bras Ginecol Obstet ; 462024.
Article em En | MEDLINE | ID: mdl-39380590
ABSTRACT

Objective:

To compare the effectiveness and safety of non-mRNA versus mRNA COVID-19 vaccines on pregnant women and their newborns in a systematic review with meta-analysis. Data sources We searched PubMed, Embase, and Cochrane Central in May 2023. Study selection The search strategy yielded 4451 results, 16 studies were fully reviewed. We selected case-control studies analysing non-mRNA versus mRNA vaccines. Data collection and

analysis:

we assessed the risk of bias using the Cochrane Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool. Standardised mean differences were pooled using random-effect models. Data

synthesis:

We identified 8 prospective and retrospective studies with a total of 32,153 patients. Non-mRNA vaccines were associated with a higher incidence of fever (OR 2.67; 95% CI 2.08-3.43; p<0.001), and a lower incidence of fetal or neonatal death (OR 0.16; 95% CI 0.08-0.33; p<0.001). In subgroup analyses, the Jansen vaccine (Ad26.COV2.S) was found to have a higher rate of premature labor/delivery (OR 4.48; 95% CI 1.45-13.83; p=0.009) and missed/spontaneous abortion (OR 1.90; 95% CI 1.09-3.30; p=0.02), as compared with the Pfizer (BNT162b2) vaccine.

Conclusion:

non-mRNA vaccines are associated with a lower incidence of fetal or neonatal death among pregnant women who receive a Covid19 vaccine, although at an increased rate of pyrexia compared with mRNA vaccines. Other studies are required for better assessment. PROSPERO CRD42023421814.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Vacinas contra COVID-19 / COVID-19 / Vacinas de mRNA Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Rev Bras Ginecol Obstet Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Vacinas contra COVID-19 / COVID-19 / Vacinas de mRNA Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Rev Bras Ginecol Obstet Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil