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The efficacy of botulinum toxin in neuropathic pain: a systematic review.
Oliveira, Kaísa Menezes; Barreto, Eduardo Silva Reis; Alencar, Vinicius Borges; Lins-Kusterer, Liliane Elze Falcão; Azi, Liana Maria Torres de Araujo; Kraychete, Durval Campos.
Afiliação
  • Oliveira KM; School of Medicine, Federal University of Bahia, Salvador, Brazil.
  • Barreto ESR; School of Medicine, Federal University of Bahia, Salvador, Brazil.
  • Alencar VB; School of Medicine, Federal University of Bahia, Salvador, Brazil.
  • Lins-Kusterer LEF; School of Medicine, Federal University of Bahia, Salvador, Brazil.
  • Azi LMTA; School of Medicine, Federal University of Bahia, Salvador, Brazil.
  • Kraychete DC; School of Medicine, Federal University of Bahia, Salvador, Brazil.
Br J Pain ; 18(5): 388-402, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39372103
ABSTRACT

Introduction:

Neuropathic pain (NP) is characterised as a lesion or disease directly affecting the somatosensory system. This study aims to analyse the efficacy of botulinum toxin type A (BT-A) in the treatment of neuropathic pain.

Methods:

This systematic literature review, guided by PRISMA, applied the PICO strategy with the following criteria (P = patients with neuropathic pain, I = botulinum toxin, C = placebo or active drug, and O = pain relief).

Results:

Fourteen articles, all randomised controlled trials with a placebo control, were included in the review. A total of 645 patients were randomised, with 353 patients receiving treatment with botulinum toxin type A in doses ranging from 25U to 400U. The evaluated studies addressed trigeminal neuralgia, diabetic polyneuropathy, post-herpetic neuralgia, spinal cord injury, phantom limb pain, and peripheral neuropathic pain after trauma or surgery.

Conclusion:

BT-A has emerged as a promising treatment for various origins of neuropathic pain. Therefore, future studies should adopt stricter criteria regarding dosage and routes of administration to ensure effective and consistent BT-A application.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Br J Pain Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Br J Pain Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido