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Could aerobic exercise applied before constraint-induced movement therapy change circulating molecular biomarkers in chronic post-stroke?
García-Salazar, Luisa Fernanda; Pereira, Natalia Duarte; Silva, Erika Shirley Moreira; Ribeiro, Jean Alex Matos; Nagai Ocamoto, Gabriela; Mendes Zambetta, Rafaella; de Oliveira, Simone Garcia; Catai, Aparecida Maria; Borstad, Alexandra; Russo, Thiago Luiz.
Afiliação
  • García-Salazar LF; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
  • Pereira ND; School of Medicine and Health Sciences, Rehabilitation Science Research Group, Universidad del Rosario, Bogotá, Colombia.
  • Silva ESM; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
  • Ribeiro JAM; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
  • Nagai Ocamoto G; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
  • Mendes Zambetta R; Undergraduate Physiotherapy Program, Morgana Potrich College (FAMP), Mineiros, Brazil.
  • de Oliveira SG; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
  • Catai AM; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
  • Borstad A; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
  • Russo TL; Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, Brazil.
Physiother Theory Pract ; : 1-12, 2024 Oct 06.
Article em En | MEDLINE | ID: mdl-39370701
ABSTRACT

BACKGROUND:

Integrating aerobic exercise (AE) into rehabilitation programs for post-stroke individuals could enhance motor recovery and cardiovascular health by increasing brain-derived neurotrophic factor (BDNF) and the myokine irisin. Chronic stroke survivors typically exhibit elevated matrix metalloproteinase-9 (MMP-9) activity, which is negatively correlated with steps and time in medium cadence, although the impact of AE on this biomarker remains unclear.

OBJECTIVE:

To evaluate the effect of high-intensity AE training prior to modified constraint-induced movement therapy (mCIMT) on BDNF and irisin concentration, and on MMP-2 and MMP-9 activity in chronic post-stroke individuals and to associate these results with functional improvements.

METHODS:

Nine participants received AE combined with mCIMT for two weeks, while the control group (n = 7) received mCIMT alone. Manual dexterity and functional capacity were assessed before and after the intervention. Serum samples were analyzed for BDNF, irisin, MMP-2 and MMP-9.

RESULTS:

There were no significant main effects of assessment, group or interaction on molecular biomarkers. However, the AE group had a significant increase in MMP-9 activity post-intervention (p = .033; d = 0.67). For the Box and Block Test, there were significant main effects of assessment (F [1, 14] = 33.27, p = .000, ηp2 = 0.70) and group (F [1, 14] = 5.43, p = .035, ηp2 = .28). No correlations were found between biomarkers and clinical assessments.

CONCLUSION:

AE prior to mCIMT did not influence circulating BDNF and irisin levels but did induce an acute rise in MMP-9 activity, suggesting potential effects on cardiovascular remodeling in this population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Physiother Theory Pract Assunto da revista: MEDICINA FISICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Physiother Theory Pract Assunto da revista: MEDICINA FISICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido