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IMP3, CDK4, MDM2 and ß-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility.
Losada, Daniele Moraes; Etchebehere, Maurício; Cintra, Francisco Fontes; Amstalden, Eliane Maria Ingrid.
Afiliação
  • Losada DM; Department of Pathology, Universidade Estatual de Campinas (Unicamp), Campinas, SP, Brazil. Electronic address: danielelosada@hotmail.com.
  • Etchebehere M; Hospital de Clínicas da Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.
  • Cintra FF; Hospital de Clínicas da Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.
  • Amstalden EMI; Department of Pathology, Universidade Estatual de Campinas (Unicamp), Campinas, SP, Brazil.
Clinics (Sao Paulo) ; 79: 100483, 2024.
Article em En | MEDLINE | ID: mdl-39368400
ABSTRACT

INTRODUCTION:

The role of IMP3, CDK4, MDM2 and ß-catenin proteins in Enchondroma and Central Chondrosarcoma is not totally understood. The aim of this study is to evaluate the immunoexpression of these proteins, associating histological grade, clinical data and prognosis to these tumors.

METHODS:

This is a retrospective-analytical study of 32 Enchondroma and 70 Central Chondrosarcoma.

RESULTS:

IMP3, CDK4, MDM2 and ß-catenin expression was observed in 22.82 %, 13.82 %, 17.17 % and in 8.8 % of cases, respectively. All Enchondromas positive for these immunomarkers were located in short tubular bones. The positivity for these antibodies is directly proportional to Chondrosarcoma's histological grade increase. No difference was found between Enchondroma and Chondrosarcoma, Grade 1 for IMP3, CDK4 and ß-catenin positivity. Significant metastasis outcome was observed for IMP3, CDK4, MDM2 and death for MDM2 expression.

CONCLUSION:

IMP3, CDK4, MDM2 and ß-catenin expression in Enchondromas of short bones phenotypically characterizes these tumors. Their expression has not proven to be useful either as diagnostic markers of these neoplasms or in distinguishing between Enchondroma and Chondrosarcoma, Grade 1. The significant immunoexpression of IMP3, CDK4 and MDM2 in metastatic Chondrosarcoma and the lower survival in those with positivity for MDM2 suggest a possible association of these proteins with tumor aggressiveness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Imuno-Histoquímica / Biomarcadores Tumorais / Condroma / Condrossarcoma / Proteínas Proto-Oncogênicas c-mdm2 / Quinase 4 Dependente de Ciclina / Beta Catenina Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Imuno-Histoquímica / Biomarcadores Tumorais / Condroma / Condrossarcoma / Proteínas Proto-Oncogênicas c-mdm2 / Quinase 4 Dependente de Ciclina / Beta Catenina Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Clinics (Sao Paulo) Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos