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Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.
Gutiérrez-García, Beatriz; Cáceres, Cynthia M; Núñez-Marín, Fidel; Molero, Jaume; Prats, Lluis; Mestre, Neus; Martínez, Silvia; Teixidor, Pilar; Comas, Silvia; Balañà, Carme; Villà, Salvador.
Afiliação
  • Gutiérrez-García B; Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. bggarcia@iconcologia.net.
  • Cáceres CM; Neuropsychology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Núñez-Marín F; Radiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Molero J; Radiophysics and Radiological Protection, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Prats L; Radiophysics and Radiological Protection, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Mestre N; Biostatistics, Centro de Regulación Genómica, Barcelona, Spain.
  • Martínez S; Neuropsychology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Teixidor P; Neurosurgery, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Comas S; Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Balañà C; Medical Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Villà S; Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Clin Transl Oncol ; 2024 Oct 05.
Article em En | MEDLINE | ID: mdl-39367900
ABSTRACT

PURPOSE:

While treatments for primary brain tumors increase survival, they have cognitive sequelae. Neurocognition's anatomical distribution makes it susceptible to brain damage. This study aims to evaluate the contribution of radiotherapy on short-term cognitive impairment. METHODS/PATIENTS Using a prospective database of cognitive rehabilitation in adults operated on for primary brain tumors, a retrospective sub-analysis of the contribution of radiotherapy was performed. Thirty-four subdivisions of 12 neurocognitive regions were delineated in 48 irradiated patients and 30 non-irradiated patients. In the first group, the correlation between radiation dose and deterioration was evaluated. In all patients, the impact of tumor and surgical changes on dysfunction was calculated and compared with dose-dependent response.

RESULTS:

The correlation between cognitive status and radiation dose is especially strong and significant in the left hemisphere and in specific subdivisions such as the posterior hippocampus or the dorsolateral prefrontal cortex, with the left prevailing over posterior dominance. Memory is the most affected domain 1 month after radiotherapy, as attention is three months later. The hippocampus is involved in various cognitive domains in addition to memory. The prefrontal subregions and the genu of the corpus callosum are more affected by the relationship with disease and surgical changes than by radiation exposure. Patients ongoing a course of radiotherapy do not benefit from concurrent cognitive rehabilitation.

CONCLUSIONS:

There is a correlation between the dose of radiation received by several encephalic regions and degree of short-term domain-specific cognition decline, considering other factors of risk and cognitive rehabilitation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália