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A Mg Battery-Integrated Bioelectronic Patch Provides Efficient Electrochemical Stimulations for Wound Healing.
Ma, Xuenan; Zhou, Yan; Xin, Meiying; Yuan, Hongming; Chao, Danming; Liu, Fangmeng; Jia, Xiaoteng; Sun, Peng; Wang, Caiyun; Lu, Geyu; Wallace, Gordon.
Afiliação
  • Ma X; State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
  • Zhou Y; State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
  • Xin M; Jilin Provincial Key Laboratory of Pediatric Neurology, Department of Pediatric Neurology, The First Hospital of Jilin University, Changchun, 130021, China.
  • Yuan H; College of Animal Sciences, Jilin University, Changchun, 130062, China.
  • Chao D; College of Chemistry, Jilin University, Changchun, 130012, China.
  • Liu F; State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
  • Jia X; International Center of Future Science, Jilin University, Changchun, 130012, China.
  • Sun P; State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
  • Wang C; State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, 130012, China.
  • Lu G; International Center of Future Science, Jilin University, Changchun, 130012, China.
  • Wallace G; Intelligent Polymer Research Institute, Faculty of Engineering and Information Sciences, University of Wollongong, North Wollongong, NSW, 2500, Australia.
Adv Mater ; : e2410205, 2024 Oct 03.
Article em En | MEDLINE | ID: mdl-39361260
ABSTRACT
Bioelectronic patches hold promise for patient-comfort wound healing providing simplified clinical operation. Currently, they face paramount challenges in establishing long-term effective electronic interfaces with targeted cells and tissues due to the inconsistent energy output and high bio interface impedance. Here a new electrochemical stimulation technology is reported, using a simple wound patch, which integrates the efficient generation and delivery of stimulation. This is realized by employing a hydrogel bioelectronic interface as an active component in an integrated power source (i.e., Mg battery). The Mg battery enhances fibroblast functions (proliferation, migration, and growth factor secretion) and regulates macrophage phenotype (promoting regenerative polarization and down-regulating pro-inflammatory cytokines), by providing an electric field and the ability to control the cellular microenvironment through chemical release. This bioelectronic patch shows an effective and accelerated wound closure by guiding epithelial migration, mediating immune response, and promoting vasculogenesis. This new electrochemical-mediated therapy may provide a new avenue for user-friendly wound management as well as a platform for fundamental insights into cell stimulation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Adv Mater Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Adv Mater Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha