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Suramin enhances proliferation, migration, and tendon gene expression of human supraspinatus tenocytes.
Huang, Shih-Hao; Wang, Chih-Chien; Shen, Po-Chih; Liu, Zi-Miao; Chen, Shu-Jung; Tien, Yin-Chun; Lu, Cheng-Chang.
Afiliação
  • Huang SH; Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
  • Wang CC; Department of Anesthesiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Shen PC; Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
  • Liu ZM; School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Chen SJ; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Tien YC; Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Lu CC; Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
J Orthop Res ; 2024 Oct 02.
Article em En | MEDLINE | ID: mdl-39358851
ABSTRACT
Rotator cuff tendinopathy is a common musculoskeletal disorder with limited pharmacological treatment strategies. This study aimed to investigate tenocytes' functional in vitro response from a ruptured supraspinatus tendon to suramin administration and to elucidate whether suramin can enhance tendon repair and modulate the inflammatory response to injury. Tenocytes were obtained from human supraspinatus tendons (n = 6). We investigated the effect of suramin on LPS-induced inflammatory responses and the underlying molecular mechanisms in THP-1 macrophages. Suramin enhanced the proliferation, cell viability, and migration of tenocytes. It also increased the protein expression of PCNA and Ki-67. Suramin-treated tenocytes exhibited increased expression of COL1A1, COL3A1, TNC, SCX, and VEGF. Suramin significantly reduced LPS-induced iNOS, COX2 synthesis, inflammatory cytokine TNF-α production, and inflammatory signaling by influencing the NF-κB pathways in THP-1 cells. Our results suggest that suramin holds great promise as a therapeutic option for treating rotator cuff tendinopathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Orthop Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Orthop Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Estados Unidos