[Thrombopoietin-mediated regulation of hematopoietic stem cells].
Rinsho Ketsueki
; 65(9): 872-877, 2024.
Article
em Ja
| MEDLINE
| ID: mdl-39358285
ABSTRACT
Sustaining lifelong hematopoiesis requires maintenance, proliferation, and differentiation of hematopoietic stem cells. Thrombopoietin is a cytokine essential for regulation of hematopoietic stem cells as well as differentiation and maturation of megakaryocytes required for platelet production. Due to these properties, thrombopoietin agonists have been used to treat bone marrow failure syndromes such as aplastic anemia. Through analysis of thrombopoietin gene-deficient mice, my colleagues and I have demonstrated the mechanism of action of thrombopoietin receptor agonists in hematopoietic stem cell maintenance and differentiation. This review focuses on governance of homeostasis in the hematopoietic system by thrombopoietin signaling.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombopoetina
/
Células-Tronco Hematopoéticas
/
Transdução de Sinais
/
Receptores de Trombopoetina
Limite:
Animals
/
Humans
Idioma:
Ja
Revista:
Rinsho Ketsueki
Ano de publicação:
2024
Tipo de documento:
Article
País de publicação:
Japão