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Cytotoxic Impact of Naringenin-Loaded Solid Lipid Nanoparticles on RIN5F Pancreatic ß Cells via Autophagy Blockage.
Mohammadi Pour, Pardis; Nouri, Zeinab; Ghasemi, Dariush; Sajadimajd, Soraya; Farzaei, Mohammad Hosein.
Afiliação
  • Mohammadi Pour P; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Nouri Z; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Ghasemi D; Kimia Andisheh Teb Medical and Molecular Laboratory Research Co., Tehran, Iran.
  • Sajadimajd S; Department of Biology, School of Sciences, Razi University, Kermanshah, Iran.
  • Farzaei MH; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Recent Adv Drug Deliv Formul ; 18(4): 304-314, 2024.
Article em En | MEDLINE | ID: mdl-39356101
ABSTRACT

BACKGROUND:

Autophagy plays a crucial role in modulating the proliferation of cancer diseases. However, the application of Naringenin (Nar), a compound with potential benefits against these diseases, has been limited due to its poor solubility and bioavailability.

OBJECTIVE:

This study aimed to develop solid lipid nanoparticles (Nar-SLNs) loaded with Nar to enhance their therapeutic impact.

METHODS:

In vitro experiments using Rin-5F cells exposed to Nar and Nar-SLNs were carried out to investigate the protective effects of Nar and its nanoformulation against the pancreatic cancer cell line of Rin-5F.

RESULTS:

Treatment with Nar and Nar-SLN led to an increase in autophagic markers (Akt, LC3, Beclin1, and ATG genes) and a decrease in the level of miR-21. Both Nar and Nar-SLN treatments inhibited cell proliferation and reduced the expression of autophagic markers. Notably, Nar-SLNs exhibited greater efficacy compared to free Nar.

CONCLUSION:

These findings suggest that SLNs effectively enhance the cytotoxic impact of Nar, making Nar-SLNs a promising candidate for suppressing or preventing Rin-5F cell growth.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Flavanonas / Proliferação de Células / Nanopartículas Limite: Animals / Humans Idioma: En Revista: Recent Adv Drug Deliv Formul Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Irã País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Flavanonas / Proliferação de Células / Nanopartículas Limite: Animals / Humans Idioma: En Revista: Recent Adv Drug Deliv Formul Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Irã País de publicação: Holanda